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= base stations; = mobile phones

The role of nitric oxide

This page of links has been put together because nitric oxide (NO) is one of the most important molecules in the body. Many processes depend upon it, are mediated by it, regulate it, or are influenced by it. It must be one of the most popular molecules for research right now. What is particularly interesting is that the production (or synthesis) of NO in the body is affected by electromagnetic radiation. Moreover, if you were to disturb NO synthesis deliberately, you would probably stimulate the same list of effects as we see in electro-hypersensitivity, even motor neurone disease, fibromyalgia and cancer. All the concerns over permeability of the blood-brain barrier, to calcium efflux and sleep disorders have links right back to nitric oxide. These links have been developed from researching the connection between effects from EMFs such as found throughout the other links pages, and nitric oxide.

That, if nothing else, makes NO well worth looking at.

Keep up with the latest nitric oxide news


EM fields, EHS and epilepsy

Mobile and radiocommunications combined with poor lifestyle: how our health is in danger from stimulation of nitric oxide free radicals, Ulrich Warnke, 2005 (in German: translation forthcoming)

Increase in nitric oxide and cyclic GMP of rat cerebellum by radio frequency burst-type electromagnetic field radiation. Miura M, Takayama K and Okada J, Japan, 2003. ‘This indicates that radiation activates NO synthase and ultimately induces vasodilatation.’ Link to nosebleeds?

Cardiovascular risk in operators under radiofrequency electromagnetic radiation, K Vangelova et al., 2006. A nitric oxide effect?

Electromagnetic fields inhibit endothelin-1 production stimulated by thrombin in endothelial cells. Morimoto et al.: ‘EMF radiation modulates ET-1 production in cultured vascular endothelial cells and the inhibitory effect of EMF radiation is, at least partly, mediated through a nitric oxide-related pathway.’

Ultra-wideband pulses increase nitric oxide production by RAW 264.7 macrophages incubated in nitrate. Seaman et al.: ‘a possible action of UWB pulses on induced nitric oxide synthase under certain conditions.’

Exposure to EMF released by mobile phones (900 MHz) increase NO levels in the sinus and nasal mucosa, Yariktas, Doner et al., Isparta, 2005

Role of Nitric Oxide in motor neurone disease (MND), Chou SM, Wang HS, Taniguchi A

Nitric oxide mediates the effects of pulsed electromagnetic field stimulation on the osteoblast proliferation and differentiation, Diniz P, Soejima K, Ito G, Kagoshime, 2002

Enhancement of nitric oxide generation by low frequency electromagnetic field, Yoshikawa T, Tanigawa M, Tanigawa T, Imai A, Hongo H, Kondo M

Nitric oxide transforms serotonin into an inactive form and this affects neuromodulation. Fossier P, Blanchard B, Ducrocq C, Leprince C, Tauc L, Baux G. Note: melatonin is produced from serotonin. See next:

Melatonin inhibits expression of the inducible isoform of nitric oxide synthase in murine macrophages: role of inhibition of NFκB activation, Gilad et al. In other words if melatonin is inhibited, nitric oxide has greater free rein ... and also (see above) suppresses further production of melatonin.

Understand the importance of melatonin.

Mitochondrial Function and Nitric Oxide Utilization

Nitric Oxide reviews: contains reasons for taking the effect of EMR on NO regulation seriously

Effects of electromagnetic field on free-radical proceses in steelworkers. Part I: Magnetic field influence on antioxidant activity in red blood cells and plasma.

Nitric Oxide Is Involved in Acetylcholinesterase Inhibitor-Induced Myopathy in Rats. Parkinson’s Institute California. Linked to Gulf War and chronic fatigue syndrome

Chronic Fatigue and Fibromyalgia: a nitric oxide vicious cycle

Effects of electromagnetic radiation from a cellular telephone on the oxidant and antioxidant levels in rabbits. Irmak MK, Fadillioglu E, Gulec M, Erdogan H, Yagmurca M, Akyol O. This finding may indicate the possible role of increased oxidative stress in the pathophysiology of adverse effect of EMR. Decreased Nitric Oxide (NO) levels may also suggest a probable role of NO in the adverse effect.

Nitric oxide metabolism pathways

The importance of Nitric Oxide

More on the importance and roles of nitric oxide

Inducible Nitric Oxide Synthase — Time for Reappraisal. A must-read if you’ve started to realise the importance of NO as a possible reason for raised cancer incidence around masts, as at Naila, Saarland.

Effects of ELF magnetic fields on protein expression profile of human breast cancer cell MCF7. A Chinese study. See next link.

Nitric oxide nitrates tyrosine residues of tumor-suppressor p53 protein in MCF-7 cells. Another enzyme effect.

Nitric oxide: from menace to marvel. Nitric oxide, synthesised from the amino acid L-arginine, literally in cells from head to foot, can keep us fit and healthy

Nitric Oxide and Blood-Brain Barrier Integrity. Is this how EMF acts on the BBB?

NO is a free radical. Read this very clear description about the role of free radicals

An important explanation of peroxynitrite, the end product of nitric oxide synthesis. Note effect on DNA.

NO generates cellular DNA damage only inefficiently and can even protect from DNA damage by H2O2, but it selectively inhibits the repair of oxidative DNA base modifications.

Is the Arginine-Nitric Oxide Pathway Involved in the Pathogenesis of Schizophrenia?,Yanik et al., Jnl Neurosychobiology, 2003

Microwave bioeffect congruence with schizophrenia, McMurtrey, 2002

Neuronal nitric oxide synthase gene polymorphism and IgE-mediated allergy in the Central European population. IgE is significant in the modern escalation of asthma. If EMR stimulates nitric oxide synthase, it may be a contributory cause.

Neutrophils, Nitric Oxide Synthase, and Mutations in the Mutatect Murine Tumor Model (see also our cell/cancer links)


Protective effects of melatonin and caffeic acid phenethyl ester against retinal oxidative stress in long-term use of mobile phone: A comparative study

Mobile phones can trigger eye damage, fear (Israeli) scientists

Cell phone radiation may cause visual damage

May nitric oxide molecule have a role in the pathogenesis of human cataract?

Expression of nitric oxide synthase-2 (NOS-2) in reactive astrocytes of the human glaucomatous optic nerve head.

Scientists discover way to block blindness from glaucoma patients. Because the cause is too much nitric oxide. (use Ctrl+F to find ‘nitric’ half way through this page)

Personal wireless communication radiation and the eye lens, James Lin, 2003. The references for this article are revealing: effects on the eye lens have been noted from microwave sources for a long time.


See Fertility


Pulsed electromagnetic fields (PEMF ir diapulse) are used everywhere for healing non-union fractures and intractable soft tissue injuries. This is well known and a great deal of work has been done since Robert Becker’s seminal work from the 1940s to the 1980s. The question is, how does it work? Two forms of stimulus work: pulsed EMF induces cell growth (and may also be harmful) while DC currents appear to stimulate regeneration through cell dedifferentiation. Interestingly, the nitric oxide link may again provide a clue.

Bone healing regulated by nitric oxide: an experimental study in rats

Microcirculatory effects of pulsed electromagnetic fields. Unexplained by the study, but NO upregulation was not considered.

Effect of nitric oxide on mouse clonal osteogenic cell, mc3t3-e1, proliferation in vitro, ie, NO enhances bone healing

Electrical signals control wound healing through phosphatidylinositol-3-OH kinase-γ and PTEN, which suggests gene-expression is altered, and argument for enzyme over-production.

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